Gut health to get improved by Nitrogen
Scientists have recently found that intestinal nitrogen plays a key role in further regulating gut microbes. Notably, this finding may help you to better understand how our diet impacts the microbiota. “There are many different diet strategies that would claim to promote gut health, and until now it has been very difficult to establish a clear causality between various types of diet and their effects on the host’s microbiome,” said Andrew Holmes, associate professor at the University of Sydney.
“The simple explanation of everything is that when we eat in a way that would encourage cooperation between ourselves and bacteria we achieve a good microbiome, but when we eat in a way that does not require cooperation this lets the bacteria do whatever they want – and mischief can ensue,” he said.
The balance of the gut bacteria in the microbiome plays a key role in such functions as the immune regulation and digestive well-being, and has been linked to other health outcomes for example obesity.
Past studies have further identified as a several patterns for how diet influences the microbiome, yet this has not led to a workable model that would explain microbial response across many different types of diets.
The new research is the latest in a series stemming from a seminal study in which the 25 different diets composed of different amounts of proteins, carbohydrates and fat were systematically varied in 858 mice.
Despite the huge diversity of gut bacteria, two main response patterns has further emerged in the study – microbe species either increased or decreased in their abundance while depending on the animal protein and carbohydrate intake.
The new model suggests that while high-carbohydrate diets were the most likely to support positive interactions in the microbiome, such benefits were relative to the protein intake of the host animal.
Researchers hope the new findings will lay the foundations for more accurate computer simulations to test hundreds of different diet variants, helping to better predict which dietary combinations lead to optimal gut health.
The study was published in the journal Cell Metabolism.