Lionel Messi has made 500 appearances for the Barcelona as the European champions moved back to the peak of the table with 4-0 victory over Real Betis.
Atletico Madrid remained equal on points with two goals in the final from Angel Correa and Antoine Griezmann to emerge 2-0 victory at Rayo Vallecano.
Christiano Ronaldo scored double and missed a penalty as Real Madrid eased the pressure on under-fire coach Rafael Benitez with a 3-1 win over Real Sociedad to reside two points behind the Real Madrid.
Barcelona celebrated their fifth trophy of 2015. Messi leading the team in the absence of Andres Iniesta.